Endocrine Abstracts

21-hydroxylase deficiency is by far (>90%) the most common cause of congenital adrenal hyperplasia (CAH). Undiagnosed and untreated 21-hydoxylase deficiency bears the risk of salt loss, adrenal insufficiency and sex misassignment, therefore early diagnosis is very important. The most common way to identify children affected by the enzyme defect is the measurement of blood levels of adrenal hormones and precursor steroids, which is an invasive method and may lead to inaccur...

The aim of the study was to investigate insulin resistance, dyslipidemia and atherogenic factors influencing HDL functions in symple obesity (SO) and obesity with acanthosis nigricans (OAN). Althogether 37 children with obesity, 17 girls and 20 boys, 19 with SO and 18 with OAN, were included into the study. Their age was 14.2±1.8 years and BMI was 35.9±6.1 kg/m2.Fasting glucose (FG), insulin (INS) were measured and HOMA-IR was calcul...

Growth hormone deficient (GHD) children born small-for-gestational-age (SGA) receive the same hGH dose as the children born with appropriate weight/length for gestational age (AGA). There are very few data on their lower growth response to the usual GH replacement dose. The aim of this multi-centre retrospective study is to analyse the hGH dose dependency of GHD children with SGA.SGA was defined as a birth weight/length below – 2 SD for gestational ...